-transparent.png){kind=logo}
B6C3F1 mice and Wistar rats were exposed to [1,4-14C]1,3-butadiene in a closed exposure system. Based on body weight, mice metabolized the test compound at about twice the rate, compared to rats. Nucleoproteins and DNA were isolated from the livers of the animals and covalent binding of [14C]-butadiene-derived radioactivity was determined. In both species comparable amounts of radioactivity were covalently bound to liver DNA. Covalent binding to mouse-liver nucleoproteins was twice as high as in rats and thus it paralleled the higher metabolic rate for butadiene in this species.
Related Publications
R Kreiling, and
R J Laib, and
H M Bolt
June 2004,
Chemico-biological interactions,
R Kreiling, and
R J Laib, and
H M Bolt
January 1993,
Archives of toxicology,
R Kreiling, and
R J Laib, and
H M Bolt
May 2003,
Chemico-biological interactions,
R Kreiling, and
R J Laib, and
H M Bolt
January 1998,
Mutation research,
R Kreiling, and
R J Laib, and
H M Bolt
August 1994,
Carcinogenesis,
R Kreiling, and
R J Laib, and
H M Bolt
February 1987,
Lancet (London, England),
R Kreiling, and
R J Laib, and
H M Bolt
August 1995,
Carcinogenesis,
R Kreiling, and
R J Laib, and
H M Bolt
June 2010,
Toxicological sciences : an official journal of the Society of Toxicology,
R Kreiling, and
R J Laib, and
H M Bolt
December 2004,
Cancer research,
R Kreiling, and
R J Laib, and
H M Bolt
June 1999,
Toxicological sciences : an official journal of the Society of Toxicology,
