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The effect of norharman on the metabolism of benzo[alpha]pyrene by rat-liver microsomes was studied. Separation of the metabolites into hydrophilic and hydrophobic fractions showed that norharman inhibited the conversion of hydrophobic metabolites to hydrophilic ones. Analysis of the hydrophobic metabolites by high-pressure liquid chromatography showed that norharman also inhibited the disappearance of benzo[alpha]pyrene itself. However, large amounts of hydrophobic metabolites, such as phenol, quinones and diols, were formed in the presence of norharman, and formation of the strong mutagen 7,8-dihydroxybenzo[alpha]pyrene was increased 10-fold by norharman. The increase in formation of this compound may be one of the chief reasons why norharman enhances the mutagenicity of benzo[alpha]pyrene on Salmonella typhimurium.
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
January 1983,
Toxicology,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
May 1975,
Cancer research,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
December 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
June 1983,
Environmental research,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
December 1975,
Cancer research,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
July 2000,
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
March 1976,
Chemico-biological interactions,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
January 1990,
Journal de toxicologie clinique et experimentale,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
October 1980,
Chemico-biological interactions,
T Fujino, and
H Fujiki, and
M Nagao, and
T Yahagi, and
Y Seino, and
T Sugimura
May 1979,
Biochemical pharmacology,
