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Immune checkpoint therapy-current perspectives and future directions. 2023
Padmanee Sharma, and
Sangeeta Goswami, and
Deblina Raychaudhuri, and
Bilal A Siddiqui, and
Pratishtha Singh, and
Ashwat Nagarajan, and
Jielin Liu, and
Sumit K Subudhi, and
Candice Poon, and
Kristal L Gant, and
Shelley M Herbrich, and
Swetha Anandhan, and
Shajedul Islam, and
Moran Amit, and
Gayathri Anandappa, and
James P Allison
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: padsharma@mdanderson.org.
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients. Varying response rates across tumor types and the need for predictive biomarkers to optimize patient selection to maximize efficacy and minimize toxicities prompted efforts to unravel immune and non-immune factors regulating the responses to ICT. This review highlights the biology of anti-tumor immunity underlying response and resistance to ICT, discusses efforts to address the current challenges with ICT, and outlines strategies to guide the development of subsequent clinical trials and combinatorial efforts with ICT.
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