The surgical pathology of rheumatic and floppy mitral valves. Distinctive morphologic features upon gross examination. 1986

J van der Bel-Kahn, and A E Becker

A total of 30 surgically resected complete mitral valves were examined, without prior knowledge of the clinical history, to evaluate the reliability of gross inspection only for the correct morphological diagnosis. Twenty valves were rheumatic; 10 were obtained from patients with idiopathic mitral valve prolapse. Two groups were identified: group I correlated with a rheumatic history; group II showed floppy mitral valves, which correlated with mitral valve prolapse. Hence, it is considered that the diagnosis of rheumatic or floppy mitral valve can be established accurately upon gross examination only. The rheumatic valve is fibrotic and firm, leading to thickening and fusion of leaflets and commissures. Narrowing and lowering of the "principal" ostium occurs. This results in a funnel-shaped valve, which is further accentuated by interchordal fusion. Rigidity is its hallmark. Chordal rupture is unlikely. Calcification can be found anywhere in the valve. Hooding is extremely unusual. The floppy valve, by contrast, shows laxity of leaflets, which may lead to the formation of dome-like deformities reaching above the level of the annulus. The chordae are often thin, attenuated, and may have ruptured. The distribution of chordae and mode of anchoring is often chaotic. Fibrosis occurs mainly at the anchoring sites of the chordae underneath or at the margin of the leaflet, or where previously ruptured, intertwined chordae are plastered underneath the dome. Fibrosis is further aggravated at the margins and atrial surface of the leaflets because of regurgitant friction. In spite of fibrosis, the floppy valve remains soft and flexible. Commissural fusion is absent. Interchordal fusion is not a characteristic feature of the floppy mitral valve. Gross inspection will not only correctly discriminate between a rheumatic and floppy mitral valve, but may also contribute to an understanding of the pathogenesis of the valve deformity.

UI MeSH Term Description Entries
D008943 Mitral Valve The valve between the left atrium and left ventricle of the heart. Bicuspid Valve,Bicuspid Valves,Mitral Valves,Valve, Bicuspid,Valve, Mitral,Valves, Bicuspid,Valves, Mitral
D008945 Mitral Valve Prolapse Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA. Floppy Mitral Valve,Mitral Click-Murmur Syndrome,Systolic Click-Murmur Syndrome,Click-Murmur Syndrome,Mitral Valve Prolapse Syndrome,Prolapsed Mitral Valve,Click Murmur Syndrome,Click-Murmur Syndrome, Mitral,Click-Murmur Syndrome, Systolic,Click-Murmur Syndromes,Floppy Mitral Valves,Mitral Click Murmur Syndrome,Mitral Valve Prolapses,Mitral Valve, Floppy,Mitral Valve, Prolapsed,Mitral Valves, Floppy,Mitral Valves, Prolapsed,Prolapse, Mitral Valve,Prolapsed Mitral Valves,Prolapses, Mitral Valve,Syndrome, Click-Murmur,Syndrome, Mitral Click-Murmur,Syndrome, Systolic Click-Murmur,Syndromes, Click-Murmur,Systolic Click Murmur Syndrome,Valve Prolapse, Mitral,Valve Prolapses, Mitral,Valve, Prolapsed Mitral,Valves, Prolapsed Mitral
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012214 Rheumatic Heart Disease Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM. Bouillaud Disease,Bouillaud's Disease,Bouillauds Disease,Disease, Bouillaud,Disease, Bouillaud's,Disease, Rheumatic Heart,Diseases, Rheumatic Heart,Heart Disease, Rheumatic,Heart Diseases, Rheumatic,Rheumatic Heart Diseases

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