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Rabbits immunized with autologous renal tubular antigen (Fx1A) developed tubulointerstitial nephritis whereas sheep anti-Fx1A antibody administered i.v. produced glomerulonephritis (GN). This lesion showed heavy granular glomerular deposition of immunoglobulin and subepithelial electron dense deposits, early proteinuria, leucocyte independence and a temporal pattern of quantitated glomerular antibody binding distinct from that reported to occur in passive Heymann's nephritis in rats. Isoelectric focusing followed by immunoblotting of deoxycholate-soluble Fx1A antigens with the heterologous and autologous antibodies, indicated species differences in epitope recognition which could account for dissociation between the two models.
M J Nicol, and
J H Miller, and
T J Neale
January 1988,
Nephron,
M J Nicol, and
J H Miller, and
T J Neale
September 2022,
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
M J Nicol, and
J H Miller, and
T J Neale
March 1985,
American journal of veterinary research,
M J Nicol, and
J H Miller, and
T J Neale
January 1987,
Jikken dobutsu. Experimental animals,
M J Nicol, and
J H Miller, and
T J Neale
January 1993,
Neoplasma,
M J Nicol, and
J H Miller, and
T J Neale
October 1994,
Laboratory animal science,
M J Nicol, and
J H Miller, and
T J Neale
June 1992,
Laboratory animal science,
M J Nicol, and
J H Miller, and
T J Neale
September 1994,
Veterinary pathology,
M J Nicol, and
J H Miller, and
T J Neale
November 2013,
Veterinary pathology,
M J Nicol, and
J H Miller, and
T J Neale
May 2021,
Research in veterinary science,
