Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens. 2023

Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
Medical Research Center, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms, metal-organic frameworks (MOFs) have received considerable attention as potential porous crystalline nanostructures. Core-shell MOF nanoparticles (NPs) have shown different diversities, complexities, and biological functionalities, as well as significant electrochemical (EC) properties and potential bio-affinity to aptamers. As a result, the developed core-shell MOF-based aptasensors serve as highly sensitive platforms for sensing cancer biomarkers with an extremely low limit of detection (LOD). This paper aimed to provide an overview of different strategies for improving selectivity, sensitivity, and signal strength of MOF nanostructures. Then, aptamers and aptamers-modified core-shell MOFs were reviewed to address their functionalization and application in biosensing platforms. Additionally, the application of core-shell MOF-assisted EC aptasensors for detection of several tumor antigens such as prostate-specific antigen (PSA), carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), human epidermal growth factor receptor-2 (HER2), cancer antigen 125 (CA-125), cytokeratin 19 fragment (CYFRA21-1), and other tumor markers were discussed. In conclusion, the present article reviews the advancement of potential biosensing platforms toward the detection of specific cancer biomarkers through the development of core-shell MOFs-based EC aptasensors.

UI MeSH Term Description Entries
D008297 Male Males
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000073396 Metal-Organic Frameworks Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery. Metal Organic Framework,Metal-Organic Framework,Porous Coordination Polymer,Covalent Organic Framework,Porous Coordination Networks,Porous Coordination Polymers,Coordination Networks, Porous,Coordination Polymer, Porous,Coordination Polymers, Porous,Framework, Covalent Organic,Framework, Metal Organic,Framework, Metal-Organic,Frameworks, Metal-Organic,Metal Organic Frameworks,Networks, Porous Coordination,Organic Framework, Covalent,Organic Framework, Metal,Polymer, Porous Coordination,Polymers, Porous Coordination
D014408 Biomarkers, Tumor Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS. Biochemical Tumor Marker,Cancer Biomarker,Carcinogen Markers,Markers, Tumor,Metabolite Markers, Neoplasm,Tumor Biomarker,Tumor Marker,Tumor Markers, Biochemical,Tumor Markers, Biological,Biochemical Tumor Markers,Biological Tumor Marker,Biological Tumor Markers,Biomarkers, Cancer,Marker, Biochemical Tumor,Marker, Biologic Tumor,Marker, Biological Tumor,Marker, Neoplasm Metabolite,Marker, Tumor Metabolite,Markers, Biochemical Tumor,Markers, Biological Tumor,Markers, Neoplasm Metabolite,Markers, Tumor Metabolite,Metabolite Markers, Tumor,Neoplasm Metabolite Markers,Tumor Markers, Biologic,Tumor Metabolite Marker,Biologic Tumor Marker,Biologic Tumor Markers,Biomarker, Cancer,Biomarker, Tumor,Cancer Biomarkers,Marker, Tumor,Markers, Biologic Tumor,Markers, Carcinogen,Metabolite Marker, Neoplasm,Metabolite Marker, Tumor,Neoplasm Metabolite Marker,Tumor Biomarkers,Tumor Marker, Biochemical,Tumor Marker, Biologic,Tumor Marker, Biological,Tumor Markers,Tumor Metabolite Markers
D015374 Biosensing Techniques Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal. Bioprobes,Biosensors,Electrodes, Enzyme,Biosensing Technics,Bioprobe,Biosensing Technic,Biosensing Technique,Biosensor,Electrode, Enzyme,Enzyme Electrode,Enzyme Electrodes,Technic, Biosensing,Technics, Biosensing,Technique, Biosensing,Techniques, Biosensing
D049329 Nanostructures Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES. Nanomaterials,Nanostructured Materials,Material, Nanostructured,Materials, Nanostructured,Nanomaterial,Nanostructure,Nanostructured Material
D052157 Aptamers, Nucleotide Nucleotide sequences, generated by iterative rounds of SELEX APTAMER TECHNIQUE, that bind to a target molecule specifically and with high affinity. DNA Aptamer,DNA Aptamers,RNA Aptamers,Rna Aptamer,Nucleotide Aptamers,Oligonucleotide Ligands, DNA,Oligonucleotide Ligands, RNA,Aptamer, DNA,Aptamer, Rna,Aptamers, DNA,Aptamers, RNA,DNA Oligonucleotide Ligands,RNA Oligonucleotide Ligands
D057230 Limit of Detection Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure. Limits of Detection,Detection Limit,Detection Limits

Related Publications

Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
February 2021, The Analyst,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
April 2016, Biosensors & bioelectronics,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
October 2013, Advanced materials (Deerfield Beach, Fla.),
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
December 2023, Food chemistry,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
June 2021, Physical chemistry chemical physics : PCCP,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
June 2021, Journal of colloid and interface science,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
February 2015, Biosensors & bioelectronics,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
August 2023, Mikrochimica acta,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
November 2018, Analytical and bioanalytical chemistry,
Suliman Khan, and William C Cho, and Afrooz Sepahvand, and Sara Haji Hosseinali, and Arif Hussain, and Mohammad Mahdi Nejadi Babadaei, and Majid Sharifi, and Mojtaba Falahati, and Laila Abdulmohsen Jaragh-Alhadad, and Timo L M Ten Hagen, and Xin Li
December 2021, Bioelectrochemistry (Amsterdam, Netherlands),
Copied contents to your clipboard!