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The effects of therapeutic concentrations of antihypertensive drugs on catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) activities in term placental explants were studied. The enzyme activities were measured in tissue fractions using radioenzymatic techniques. At 6 h the incubation COMT activity increased significantly following exposure to verapamil and hydralazine, while exposure to alpha methyldopa caused a significant suppression of the enzyme. At 24 h exposure to hydralazine significantly suppressed the COMT activity. By 6 h the MAO activity was significantly suppressed by verapamil. MgSO4 and propranolol had no effect on the activities of COMT and MAO at 6 and 24 h. These results suggest that COMT and MAO activities in the placenta can be modulated by antihypertensive drugs and, therefore, these drugs might affect local catechol metabolism.
E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
March 1999,
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E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
January 1971,
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E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
September 1969,
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E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
October 1979,
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E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
September 1968,
The American journal of physiology,
E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
December 1976,
Life sciences,
E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
September 1969,
Scandinavian journal of clinical and laboratory investigation,
E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
May 1973,
Experientia,
E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
January 1974,
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E R Barnea, and
H Fakih, and
G Oelsner, and
S Walner, and
A H DeCherney, and
F Naftolin
August 1983,
Drug and alcohol dependence,
