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The antineoplastic activity of two ether lipid derivatives, the alkyl-lysophospholipid derivative (ALP) ET-18-OCH3 and the ether-linked lipoidal amine CP-46,665 was tested in a human tumor clonogenic assay (HTCA) in vitro. CP-46,665 suppressed the colony formation of various human tumors with a slight dose response relation after 1 hr incubation and with a clear optimum (85% response rate) after continuous exposure in the higher dose range tested (10 micrograms/ml). ET-18-OCH3 did not have substantial activity after 1 hr of incubation. However, when continuous exposure to the compound was used, ET-18-OCH3 seemed to have a modest dose response effect and yielded a response in about 60% of the tumor cell samples tested in the higher dose range (10 micrograms/ml). Thus, both compounds have in vitro antitumor activity in the HTCA within a dose range of 1-10 micrograms/ml, especially during continuous exposure. The tumor specific type activity was found in breast cancer, ovarian cancer, lung cancer and mesothelioma. Both compounds caused decreases in colony formation down to the 0%, 2% and 4% levels. In a comparison of specimens in which both compounds were used, only one of five times showed a discordance in sensitivity or resistance; therefore the compounds appear similar in their in vitro activity. In a second set of experiments we tested the structure-activity relationship among a variety of ALP in the [3H]thymidine incorporation assay after incubation with HL-60 leukemic blasts and other neoplastic cells from human origin.(ABSTRACT TRUNCATED AT 250 WORDS)
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
September 2005,
Cancer chemotherapy and pharmacology,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
January 1989,
Acta oncologica (Stockholm, Sweden),
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
October 2015,
Archives of pharmacal research,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
October 2008,
Journal of natural products,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
March 1991,
The Journal of antibiotics,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
January 1992,
APMIS. Supplementum,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
February 2003,
Free radical research,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
October 2019,
Journal of agricultural and food chemistry,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
July 2002,
Cancer chemotherapy and pharmacology,
W E Berdel, and
D D Von Hoff, and
C Unger, and
H D Schick, and
U Fink, and
A Reichert, and
H Eibl, and
J Rastetter
March 2015,
Pest management science,
