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The haemodynamic effects of intravenous mexiletine have been studied in 16 patients with valvular heart disease without clinical evidence of heart failure. A bolus injection of 150 mg administered to 6 of the 16 patients resulted in a mean plasma concentration above the therapeutic range for at least 5 minutes after the drug was given. A small but significant rise in the mean pulmonary artery pressure occurred. In 10 patients, the effects of intravenous mexiletine were compared with those of intravenous saline in a double blind trial. No significant difference was found in the haemodynamic effects, though both saline and mexiletine produced a small rise in the mean pulmonary artery pressure. Mexiletine when administered to patients without heart failure in doses known to be clinically effective did not have important adverse haemodynamic effects.
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
January 1977,
Postgraduate medical journal,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
April 1992,
The Journal of international medical research,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
January 1984,
Journal of cardiovascular pharmacology,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
January 1977,
Postgraduate medical journal,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
January 1977,
Postgraduate medical journal,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
November 1975,
Cardiovascular research,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
September 1991,
Clinical pharmacology and therapeutics,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
November 1983,
Giornale italiano di cardiologia,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
May 1984,
American heart journal,
N P Campbell, and
S A Zaidi, and
A A Adgey, and
G C Patterson, and
J F Pantridge
December 1979,
Archives des maladies du coeur et des vaisseaux,
