Biomaterial Database

The microbiota-gut-brain axis and neurodevelopmental disorders. 2023

Qinwen Wang, and Qianyue Yang, and Xingyin Liu

State Key Laboratory of Reproductive Medicine and offspring Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. In recent years, the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly appreciated. The gut microbiota is commonly considered to regulate neurodevelopment through three pathways, the immune pathway, the neuronal pathway, and the endocrine/systemic pathway, with overlaps and crosstalks in between. Accumulating studies have identified the role of the microbiota-gut-brain axis in neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, and Rett Syndrome. Numerous researchers have examined the physiological and pathophysiological mechanisms influenced by the gut microbiota in neurodevelopmental disorders (NDDs). This review aims to provide a comprehensive overview of advancements in research pertaining to the microbiota-gut-brain axis in NDDs. Furthermore, we analyzed both the current state of research progress and discuss future perspectives in this field.

UI	MeSH Term	Description	Entries
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000067877	Autism Spectrum Disorder	Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)	Autistic Spectrum Disorder,Autism Spectrum Disorders,Autistic Spectrum Disorders,Disorder, Autistic Spectrum
D000069196	Gastrointestinal Microbiome	All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT.	Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000087502	Brain-Gut Axis	An interactive network between the GASTROINTESTINAL TRACT (gut) and the brain principally mediated through the ENTERIC NERVOUS SYSTEM. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones (e.g., CORTICOTROPIN-RELEASING FACTOR). Conversely, INTESTINAL MICROBIOTA associate with the CENTRAL NERVOUS SYSTEM through the axis via microorganism-derived products (e.g., UROCORTINS). Some functional GASTROINTESTINAL DISORDERS (e.g., IRRITABLE BOWEL SYNDROME) have dysregulated brain-gut axis.	Brain and Gut Axis,Brain-Gut-Microbiome Axis,Gut and Brain Axis,Gut-Brain Axis,Gut-Brain-Microbiome Axis,Microbiome-Brain-Gut Axis,Microbiome-Gut-Brain Axis,Microbiota-Brain-Gut Axis,Microbiota-Gut-Brain Axis,Axis, Brain-Gut,Axis, Brain-Gut-Microbiome,Axis, Gut-Brain,Axis, Gut-Brain-Microbiome,Axis, Microbiome-Brain-Gut,Axis, Microbiome-Gut-Brain,Axis, Microbiota-Brain-Gut,Axis, Microbiota-Gut-Brain,Brain Gut Axis,Brain Gut Microbiome Axis,Gut Brain Axis,Gut Brain Microbiome Axis,Microbiome Brain Gut Axis,Microbiome Gut Brain Axis,Microbiota Brain Gut Axis,Microbiota Gut Brain Axis
D065886	Neurodevelopmental Disorders	These are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning. (From DSM-5).	Mental Disorders Usually Diagnosed in Infancy, Childhood or Adolescence,Neurodevelopmental Disorders Usually Diagnosed in Infancy, Childhood or Adolescence,Child Mental Disorders,Mental Disorders Diagnosed in Childhood,Child Mental Disorder,Disorder, Child Mental,Disorder, Neurodevelopmental,Mental Disorder, Child,Mental Disorders, Child,Neurodevelopmental Disorder