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Studies have been made on the reversible inhibition of acetylcholinesterase activity from the erythrocytes of man, horse and camel, the electric organ of the skate Torpedo marmorata and eel Electrophorus electricus, the venom of the snakes Naja naja and Vipera lebetina, the brain of the pigeon Columba livia by tetraphenyl-, triphenylalkyl- and tributyrylalkyl-phosphonium salts. The investigated phosphonium inhibitors exhibit an evident specificity in their action: they were more effective in inhibiting the acetylcholinesterase from human erythrocytes than that from the erythrocytes of horse and camel. These salts were more effective with respect to the acetylcholinesterase activity of the electric organ of the skate than that of the electric organ of the eel. Acetylcholinesterases from the venom of the snakes exhibited practically identical sensitivity to all the phosphonium compounds investigated. The present work is the first attempt to use quaternary phosphonium salts (the so-called "hydrophobic ions") in comparative enzymological investigation.
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
January 1986,
Ukrainskii biokhimicheskii zhurnal (1978),
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
January 1996,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
April 1968,
Biochemistry,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
November 1987,
Pharmazie in unserer Zeit,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
June 2018,
Water research,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
November 2023,
Future medicinal chemistry,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
November 1985,
Pharmazie in unserer Zeit,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
October 1987,
Die Pharmazie,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
January 2011,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
A P Brestkin, and
V S Brovko, and
Iu G Zhukovskiĭ, and
N A Kolchanova, and
E A Mirzabaev
January 2010,
Doklady. Biochemistry and biophysics,
