Biomaterial Database

Early pulmonary lesions caused by dead Dirofilaria immitis in dogs exposed to homologous antigens. 1986

R B Atwell, and R H Sutton, and I B Buoro

Dead adult D. immitis were inserted into the pulmonary arteries of 10 healthy pups, five of which were given a crude antigenic extract of D. immitis subcutaneously. Two dogs, one from each group were then killed 1, 3, 5, 7 and 9 days after the insertion of filariae and the associated pulmonary artery pathology examined. Microscopically, haemorrhage was evident at day 1, followed by suppuration and organization at days 5 to 7, with organization, fibrosis and focal pleural retraction evident on days 7 to 9. Within arteries haemorrhage and thrombosis was evident, particularly on days 1, 3 and 5. Histology confirmed the extent of haemorrhage evident grossly and, as no rupture was evident, suggested it to be due to diapedesis. Wall disruption occurred due to the local pressure effects of impacted filariae, but also due to inflammation, which was initially suppurative, later being replaced by plasma cell and lymphocyte involvement. Maximal wall disruption occurred at day 5 followed by organization and fibrosis. After day 5 there was more intense organization in the dogs given antigen, in association with the development of interstitial thickening, a finding previously reported in dogs with similar antigenic exposure.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008171	Lung Diseases	Pathological processes involving any part of the LUNG.	Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D008297	Male		Males
D011651	Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.	Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011655	Pulmonary Embolism	Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.	Pulmonary Thromboembolism,Thromboembolism, Pulmonary,Embolism, Pulmonary,Embolisms, Pulmonary,Pulmonary Embolisms,Pulmonary Thromboembolisms,Thromboembolisms, Pulmonary
D011658	Pulmonary Fibrosis	A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D004183	Dirofilaria immitis	A filarial parasite primarily of dogs but occurring also in foxes, wolves, and humans. The parasite is transmitted by mosquitoes.	Dog Heartworm,Dirofilaria immitides,Dog Heartworms,Heartworm, Dog,Heartworms, Dog,immitis, Dirofilaria
D004184	Dirofilariasis	Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.	Heartworm Disease,Dirofilariases,Disease, Heartworm
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females