[Cellular proliferation of the regenerating liver in rats after a single administration of N-nitrosodiethylamine]. 1986

L A Osipova, and L N Khranovskaia, and A I Bykorez

Proliferative kinetics of hepatocytes and nonparenchymal cells of the regenerating rat liver has been studied after a single injection of the carcinogen in S- or G2-M-phase cell cycle of hepatocytes. Disturbances of proliferation in the mentioned cell populations and resistance of normal proliferating hepatocytes during the S-phase of the mitotic cycle to the cytotoxic effect of the carcinogen are established. Possible mechanisms of the resistance of the proliferating cells to the toxic action of the carcinogen are discussed.

UI MeSH Term Description Entries
D007399 Interphase The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs). Interphases
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008115 Liver Regeneration Repair or renewal of hepatic tissue. Liver Regenerations,Regeneration, Liver,Regenerations, Liver
D008297 Male Males
D008862 Microsomes, Liver Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough. Liver Microsomes,Liver Microsome,Microsome, Liver
D008938 Mitosis A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. M Phase, Mitotic,Mitotic M Phase,M Phases, Mitotic,Mitoses,Mitotic M Phases,Phase, Mitotic M,Phases, Mitotic M
D010089 Oxidoreductases, N-Demethylating N-Demethylase,N-Demethylases,Oxidoreductases, N Demethylating,Demethylating Oxidoreductases, N,N Demethylase,N Demethylases,N Demethylating Oxidoreductases,N-Demethylating Oxidoreductases
D002453 Cell Cycle The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE. Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D004052 Diethylnitrosamine A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. Nitrosodiethylamine,N-Nitrosodiethylamine,N Nitrosodiethylamine

Related Publications

L A Osipova, and L N Khranovskaia, and A I Bykorez
March 1968, The Journal of cell biology,
L A Osipova, and L N Khranovskaia, and A I Bykorez
June 1986, Vrachebnoe delo,
L A Osipova, and L N Khranovskaia, and A I Bykorez
January 1968, Virchows Archiv. B, Cell pathology,
L A Osipova, and L N Khranovskaia, and A I Bykorez
April 2021, Genome research,
L A Osipova, and L N Khranovskaia, and A I Bykorez
January 2017, Oxidative medicine and cellular longevity,
L A Osipova, and L N Khranovskaia, and A I Bykorez
June 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
L A Osipova, and L N Khranovskaia, and A I Bykorez
October 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
L A Osipova, and L N Khranovskaia, and A I Bykorez
October 1969, Gan,
L A Osipova, and L N Khranovskaia, and A I Bykorez
October 2009, Cell biology and toxicology,
Copied contents to your clipboard!