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A study of the enzymes of the arachidonic acid cascade revealed a high sensitivity of prostacyclin synthetase and a complete resistance of thromboxane A2 synthetase to time-dependent destruction by an oxidant [Ox] released during the peroxidase-catalyzed reduction of hydroperoxy fatty acids. The destructive action of [Ox] derived from prostaglandin G1 (PGG1), 15-hydroperoxy-PGE1, 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, and 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid upon prostacyclin synthetase was prevented by 2-aminomethyl-4-t-butyl-6-iodophenol. On the other hand, deactivation resulting from PGG2 metabolism was neither time-dependent nor sensitive to 2-aminomethyl-4-t-butyl-6-iodophenol. The possibility that the action of [Ox] may alter the arachidonic acid cascade in favor of thromboxane A2 is discussed in view of its possible implications in inflammatory and other pathological processes.
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
October 1981,
Planta,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
June 1980,
Prostaglandins and medicine,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
December 1976,
The Journal of biological chemistry,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
April 1989,
Nihon rinsho. Japanese journal of clinical medicine,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
June 1987,
Prostaglandins, leukotrienes, and medicine,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
March 1982,
Pharmacological research communications,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
September 1989,
Biotechnology and bioengineering,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
October 1983,
The Journal of clinical investigation,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
August 1984,
Surgery,
E A Ham, and
R W Egan, and
D D Soderman, and
P H Gale, and
F A Kuehl
August 1980,
Biochemical and biophysical research communications,
