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Subsarcolemmal (SS) and interfibrillar (IF) cardiac mitochondrial respiratory activities were examined under conditions of isovolemic hemodilution in rats. Experimental animals (mean Hct, 21%) had significantly higher cardiac indices than controls (mean Hct, 41.5%) 18 hours following isovolemic hemodilution with 0.9% NaCl. A 40% increase in cardiac output was associated with a significant increase in the respiratory control index (RCI) of the IF mitochondria. This increase in IF RCI occurred as a result of a significant decline in the ADP-independent (State 4) respiratory rate. These data demonstrate the ability of cardiac mitochondria to respond to increased myocardial demand by increasing mitochondrial efficiency and support the concept of subspecialized populations of mitochondria within the myocardial cell.
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
January 1994,
Anesteziologiia i reanimatologiia,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
January 1994,
Advances in pharmacology (San Diego, Calif.),
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
January 1993,
Beitrage zur Infusionstherapie = Contributions to infusion therapy,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
August 1995,
Transfusion,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
January 1979,
Beitrage zu Infusionstherapie und klinische Ernahrung,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
May 1976,
Medizinische Monatsschrift,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
May 1974,
The American journal of physiology,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
January 1987,
Progress in clinical and biological research,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
October 2008,
Anesthesia and analgesia,
E S Weinstein, and
W W Hampton, and
M D Yokum, and
D E Fry
April 1983,
Infusionstherapie und klinische Ernahrung,
