Artificial-Intelligence-Driven Algorithms for Predicting Response to Corticosteroid Treatment in Patients with Post-Acute COVID-19. 2023

Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
Department of Telecommunications, Faculty of Electrical Engineering and Communications, Brno University of Technology, Technicka 12, 616 00 Brno, Czech Republic.

Pulmonary fibrosis is one of the most severe long-term consequences of COVID-19. Corticosteroid treatment increases the chances of recovery; unfortunately, it can also have side effects. Therefore, we aimed to develop prediction models for a personalized selection of patients benefiting from corticotherapy. The experiment utilized various algorithms, including Logistic Regression, k-NN, Decision Tree, XGBoost, Random Forest, SVM, MLP, AdaBoost, and LGBM. In addition easily human-interpretable model is presented. All algorithms were trained on a dataset consisting of a total of 281 patients. Every patient conducted an examination at the start and three months after the post-COVID treatment. The examination comprised a physical examination, blood tests, functional lung tests, and an assessment of health state based on X-ray and HRCT. The Decision tree algorithm achieved balanced accuracy (BA) of 73.52%, ROC-AUC of 74.69%, and 71.70% F1 score. Other algorithms achieving high accuracy included Random Forest (BA 70.00%, ROC-AUC 70.62%, 67.92% F1 score) and AdaBoost (BA 70.37%, ROC-AUC 63.58%, 70.18% F1 score). The experiments prove that information obtained during the initiation of the post-COVID-19 treatment can be used to predict whether the patient will benefit from corticotherapy. The presented predictive models can be used by clinicians to make personalized treatment decisions.

UI MeSH Term Description Entries

Related Publications

Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
November 2022, Diagnostics (Basel, Switzerland),
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
March 2024, Heliyon,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
September 2021, Computers in biology and medicine,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
October 2023, European review for medical and pharmacological sciences,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
September 2023, Journal of clinical medicine,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
September 2020, Current opinion in ophthalmology,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
January 2022, Studies in health technology and informatics,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
January 2022, Methods in molecular biology (Clifton, N.J.),
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
May 2020, La Radiologia medica,
Vojtech Myska, and Samuel Genzor, and Anzhelika Mezina, and Radim Burget, and Jan Mizera, and Michal Stybnar, and Martin Kolarik, and Milan Sova, and Malay Kishore Dutta
November 2020, ArXiv,
Copied contents to your clipboard!