In Vitro Virucidal Effects of Ultraviolet Light Prototypes on RNA viruses. 2023

Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Italy.

Ultraviolet-C (UVC) has been used to cause virus inactivation. The virucidal activity of three UV light lamps [UVC high frequencies (HF), UVC+B LED and UVC+A LED] was evaluated against the enveloped feline coronavirus (FCoVII), a surrogate model of SARS-CoV-2, the enveloped vesicular stomatitis virus (VSV), and the naked encephalomyocarditis virus (EMCV). Virucidal assays were performed at different time points of UV-light exposure (i.e., 5, 30 minutes and 1, 6, and 8 hours), placing each virus 180 cm below the perpendicular irradiation of the lamp and 1 and 2 meters from the perpendicular axis. We found that the UVC HF lamp had virucidal effects (≥96.8% of virus inactivation) against FCoVII, VSV and EMCV after 5 minutes of irradiation at each distance analyzed. Moreover, the UVC+B LED lamp had the highest inhibitory effects on FCoVII and VSV infectivity (≥99% of virus inactivation) when these viruses were settled below the perpendicular axis of the lamp for 5 minutes. Conversely, the UVC+A LED lamp was the least effective, achieving ≥85.9% inactivation of enveloped RNA viruses after 8 hours of UV exposure. Overall, UV light lamps, and in particular UVC HF and UVC+B LED ones, had a rapid and strong virucidal activity against distinct RNA viruses, including coronaviruses.

UI MeSH Term Description Entries
D004203 Disinfection Rendering pathogens harmless through the use of heat, antiseptics, antibacterial agents, etc.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000086382 COVID-19 A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent. 2019 Novel Coronavirus Disease,2019 Novel Coronavirus Infection,2019-nCoV Disease,2019-nCoV Infection,COVID-19 Pandemic,COVID-19 Pandemics,COVID-19 Virus Disease,COVID-19 Virus Infection,Coronavirus Disease 2019,Coronavirus Disease-19,SARS Coronavirus 2 Infection,SARS-CoV-2 Infection,Severe Acute Respiratory Syndrome Coronavirus 2 Infection,COVID19,2019 nCoV Disease,2019 nCoV Infection,2019-nCoV Diseases,2019-nCoV Infections,COVID 19,COVID 19 Pandemic,COVID 19 Virus Disease,COVID 19 Virus Infection,COVID-19 Virus Diseases,COVID-19 Virus Infections,Coronavirus Disease 19,Disease 2019, Coronavirus,Disease, 2019-nCoV,Disease, COVID-19 Virus,Infection, 2019-nCoV,Infection, COVID-19 Virus,Infection, SARS-CoV-2,Pandemic, COVID-19,SARS CoV 2 Infection,SARS-CoV-2 Infections,Virus Disease, COVID-19,Virus Infection, COVID-19
D000086402 SARS-CoV-2 A species of BETACORONAVIRUS causing atypical respiratory disease (COVID-19) in humans. The organism was first identified in 2019 in Wuhan, China. The natural host is the Chinese intermediate horseshoe bat, RHINOLOPHUS affinis. 2019 Novel Coronavirus,COVID-19 Virus,COVID19 Virus,Coronavirus Disease 2019 Virus,SARS Coronavirus 2,SARS-CoV-2 Virus,Severe Acute Respiratory Syndrome Coronavirus 2,Wuhan Coronavirus,Wuhan Seafood Market Pneumonia Virus,2019-nCoV,2019 Novel Coronaviruses,COVID 19 Virus,COVID-19 Viruses,COVID19 Viruses,Coronavirus 2, SARS,Coronavirus, 2019 Novel,Coronavirus, Wuhan,Novel Coronavirus, 2019,SARS CoV 2 Virus,SARS-CoV-2 Viruses,Virus, COVID-19,Virus, COVID19,Virus, SARS-CoV-2,Viruses, COVID19
D014466 Ultraviolet Rays That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants. Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray
D014780 Viruses Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells. Animal Viruses,Zoophaginae,Animal Virus,Virus,Virus, Animal,Viruses, Animal

Related Publications

Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
July 1973, Biomedicine / [publiee pour l'A.A.I.C.I.G.],
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
January 1969, Archiv fur klinische und experimentelle Dermatologie,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
October 1966, Journal of molecular biology,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
July 2014, Journal of microbiology and biotechnology,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
March 1984, Biochemistry,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
March 1966, Biochemical and biophysical research communications,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
January 1967, Archiv fur experimentelle Veterinarmedizin,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
January 1969, The Journal of investigative dermatology,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
January 1989, Current studies in hematology and blood transfusion,
Matteo Fracella, and Mirko Scordio, and Leonardo Sorrentino, and Alessandra D'Auria, and Raffaele Ingenito, and Massimo Gentile, and Alessandra Pierangeli, and Guido Antonelli, and Carolina Scagnolari, and Federica Frasca
January 2016, Arquivos brasileiros de oftalmologia,
Copied contents to your clipboard!