-transparent.png){kind=logo}
In 31 patients with at least 3 migraine attacks per month the prophylactic effect of tolfenamic acid 300 mg/day, propranolol 120 mg/day, and placebo was compared in a randomized double-blind cross-over study. The patients were treated for 12 weeks with each drug, but only the last 11 weeks were used for evaluation. Both tolfenamic acid and propranolol significantly reduced the number of attacks, the total duration of attacks and additional drugs taken when compared with placebo. Tolfenamic acid, but not propranolol, significantly reduced the median intensity of pain and the number of attacks confining the patients to their beds when compared with placebo. Only mild adverse reactions occurred with no significant difference between the drugs. It was concluded that the prophylactic effect of tolfenamic acid 300 mg/day in migraine was at least as good as propranolol 120 mg/day.
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
June 1994,
Acta neurologica Scandinavica,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
July 1982,
Acta neurologica Scandinavica,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
January 1994,
Pharmacology & toxicology,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
March 1983,
Cephalalgia : an international journal of headache,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
January 1974,
Acta neurologica Scandinavica,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
May 1986,
Acta neurologica Scandinavica,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
September 1982,
Cephalalgia : an international journal of headache,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
August 1997,
Cephalalgia : an international journal of headache,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
October 1984,
American heart journal,
B Mikkelsen, and
K K Pedersen, and
L V Christiansen
January 1995,
Neurologia i neurochirurgia polska,
