Biomaterial Database

Diagnostic Sensitivity of Abdominal Fat Aspiration Biopsy for Cardiac Amyloidosis: A Systematic Review and Meta-Analysis. 2024

Jiaqi Wang, and Dong Chen, and Fang Dong, and Haochen Chi

Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Introduction. Cardiac amyloidosis is a lethal disease, the incidence of which is increasing every year. Early diagnosis and treatment are the keys to reducing the mortality of this disease. Methods. Relevant English literature published in Embase, PubMed, Cochrane Library, and Web of Science were searched until December 1, 2022. Meta-analysis was performed with Stata 17.0 software. Results. A total of 1060 patients with 5 articles were included in this study. The sensitivity of abdominal fat aspiration biopsy for the diagnosis of cardiac amyloidosis was 0.66 (0.48-0.84) and the sensitivity for light chain amyloidosis cardiomyopathy and transthyretin amyloidosis cardiomyopathy was 0.90 (0.80-0.97) and 0.39 (0.18-0.60), respectively. Conclusion. Abdominal fat aspiration biopsy has high sensitivity and clinical value in the diagnosis of light chain amyloidosis cardiomyopathy, whereas there are limitations in the diagnosis of transthyretin amyloidosis cardiomyopathy.

UI	MeSH Term	Description	Entries
D009202	Cardiomyopathies	A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D044963	Biopsy, Fine-Needle	Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.	Aspiration Biopsy, Fine-Needle,Fine Needle Biopsy,Fine-Needle Aspiration,Aspiration Biopsies, Fine-Needle,Aspiration Biopsy, Fine Needle,Aspiration, Fine-Needle,Aspirations, Fine-Needle,Biopsies, Fine Needle,Biopsies, Fine-Needle,Biopsies, Fine-Needle Aspiration,Biopsy, Fine Needle,Biopsy, Fine-Needle Aspiration,Fine Needle Aspiration,Fine Needle Biopsies,Fine-Needle Aspiration Biopsies,Fine-Needle Aspiration Biopsy,Fine-Needle Aspirations,Fine-Needle Biopsies,Fine-Needle Biopsy,Needle Biopsies, Fine,Needle Biopsy, Fine
D050153	Abdominal Fat	Fatty tissue in the region of the ABDOMEN. It includes the ABDOMINAL SUBCUTANEOUS FAT and the INTRA-ABDOMINAL FAT.	Adipose Tissue, Abdominal,Abdominal Adipose Tissue,Fat, Abdominal,Abdominal Fats,Fats, Abdominal
D028227	Amyloid Neuropathies, Familial	Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.	Familial Amyloid Polyneuropathies,Amyloid Neuropathy Type 1,Amyloid Polyneuropathy, British Type,Amyloid Polyneuropathy, Iowa Type,Amyloid Polyneuropathy, Swiss Type,Appalachian Type Familial Amyloid Polyneuropathy,British Type Amyloid Polyneuropathy,Cerebral Amyloid Angiopathy, British Type,Familial Amyloid Neuropathy, Andrade Type,Familial Amyloid Neuropathy, Finnish Type,Familial Amyloid Neuropathy, Portuguese Type,Familial Amyloid Polyneuropathy, Appalachian Type,Familial Amyloid Polyneuropathy, Jewish Type,Familial Amyloid Polyneuropathy, Type I,Familial Amyloid Polyneuropathy, Type II,Familial Amyloid Polyneuropathy, Type III,Familial Amyloid Polyneuropathy, Type IV,Familial Amyloid Polyneuropathy, Type V,Familial Amyloid Polyneuropathy, Type VI,Familial Portuguese Polyneuritic Amyloidosis,Finnish Type Familial Amyloid Neuropathy,Hereditary Neuropathic Amyloidosis,Iowa Type Amyloid Polyneuropathy,Jewish Type Familial Amyloid Polyneuropathy,Neuropathic Amyloid Syndrome,Polyneuritic Amyloidosis, Portuguese,Portuguese Polyneuritic Amyloidosis,Portuguese Type Familial Amyloid Neuropathy,Swiss Type Amyloid Polyneuropathy,Type I Familial Amyloid Polyneuropathy,Type II Familial Amyloid Polyneuropathy,Type III Familial Amyloid Polyneuropathy,Type IV Familial Amyloid Polyneuropathy,Type V Familial Amyloid Polyneuropathy,Type VI Familial Amyloid Polyneuropathy,Wohlwill-Andrade Syndrome,Wohlwill-Corino Andrade Syndrome,Amyloid Neuropathy, Familial,Amyloid Polyneuropathies, Familial,Amyloid Polyneuropathy, Familial,Amyloid Syndrome, Neuropathic,Amyloid Syndromes, Neuropathic,Amyloidoses, Hereditary Neuropathic,Amyloidoses, Portuguese Polyneuritic,Amyloidosis, Hereditary Neuropathic,Amyloidosis, Portuguese Polyneuritic,Familial Amyloid Neuropathies,Familial Amyloid Neuropathy,Familial Amyloid Polyneuropathy,Hereditary Neuropathic Amyloidoses,Neuropathic Amyloid Syndromes,Neuropathic Amyloidoses, Hereditary,Neuropathic Amyloidosis, Hereditary,Neuropathies, Familial Amyloid,Neuropathy, Familial Amyloid,Polyneuritic Amyloidoses, Portuguese,Polyneuropathies, Familial Amyloid,Polyneuropathy, Familial Amyloid,Portuguese Polyneuritic Amyloidoses,Wohlwill Andrade Syndrome,Wohlwill Corino Andrade Syndrome