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A practical synthesis of 1,3-disubstituted cubane derivatives. 2023

Nahin Kazi, and Marine C Aublette, and Sarah L Allinson, and Susannah C Coote
Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, UK. s.coote@lancaster.ac.uk.

A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.

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