-transparent.png){kind=logo}
In an effort to explain the large variation of airway reactivity to histamine in human subjects in vivo, we have examined the relationship between histamine responses in vivo and isoproterenol in vitro. The bronchial reactivity in patients with lung carcinoma was assessed prior to surgery by measuring the provocative concentration of histamine that resulted in a 20 or a 40% reduction in either forced expiratory volume in one second or specific airway conductance (SGaw). We also determined the pD2 value (-Log EC50 molar) to histamine and isoproterenol in isolated bronchial muscle preparations from these subjects. A wide range of histamine responsiveness was observed in vivo for the 17 patients (PC40 SGaw: 1.3 to greater than 64 mg/ml of histamine). There was no correlation between this latter parameter and the bronchial histamine sensitivity in vitro. However, isolated bronchial muscle preparations from asthmatic subjects were less sensitive to isoproterenol than were those preparations from nonasthmatic subjects.
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
November 1983,
The American review of respiratory disease,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
July 2012,
Veterinary journal (London, England : 1997),
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
January 1995,
European journal of pharmacology,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
November 1980,
British journal of clinical pharmacology,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
June 1984,
The American review of respiratory disease,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
June 1992,
American journal of respiratory cell and molecular biology,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
January 1989,
Pulmonary pharmacology,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
January 1977,
Proceedings of the Western Pharmacology Society,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
July 1981,
The Journal of allergy and clinical immunology,
J Cerrina, and
M Le Roy Ladurie, and
C Labat, and
B Raffestin, and
A Bayol, and
C Brink
January 1980,
Acta dermato-venereologica,
