Biomaterial Database

Gut Microbiota Modulation of Short Bowel Syndrome and the Gut-Brain Axis. 2023

Jasmine Carter, and Jeffery Bettag, and Sylvia Morfin, and Chandrashekhara Manithody, and Aakash Nagarapu, and Aditya Jain, and Hala Nazzal, and Sai Prem, and Meghan Unes, and Matthew McHale, and Chien-Jung Lin, and Chelsea Hutchinson, and Grace Trello, and Arti Jain, and Edward Portz, and Arun Verma, and Marzena Swiderska-Syn, and Daniel Goldenberg, and Kento Kurashima

Department of Pediatrics, Saint Louis University, Saint Louis, MO 63104, USA.

Short bowel syndrome (SBS) is a condition that results from a reduction in the length of the intestine or its functional capacity. SBS patients can have significant side effects and complications, the etiology of which remains ill-defined. Thus, facilitating intestinal adaptation in SBS remains a major research focus. Emerging data supports the role of the gut microbiome in modulating disease progression. There has been ongoing debate on defining a "healthy" gut microbiome, which has led to many studies analyzing the bacterial composition and shifts that occur in gastrointestinal disease states such as SBS and the resulting systemic effects. In SBS, it has also been found that microbial shifts are highly variable and dependent on many factors, including the anatomical location of bowel resection, length, and structure of the remnant bowel, as well as associated small intestinal bacterial overgrowth (SIBO). Recent data also notes a bidirectional communication that occurs between enteric and central nervous systems called the gut-brain axis (GBA), which is regulated by the gut microbes. Ultimately, the role of the microbiome in disease states such as SBS have many clinical implications and warrant further investigation. The focus of this review is to characterize the role of the gut microbiota in short bowel syndrome and its impact on the GBA, as well as the therapeutic potential of altering the microbiome.

UI	MeSH Term	Description	Entries
D007421	Intestine, Small	The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.	Small Intestine,Intestines, Small,Small Intestines
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069196	Gastrointestinal Microbiome	All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT.	Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000087502	Brain-Gut Axis	An interactive network between the GASTROINTESTINAL TRACT (gut) and the brain principally mediated through the ENTERIC NERVOUS SYSTEM. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones (e.g., CORTICOTROPIN-RELEASING FACTOR). Conversely, INTESTINAL MICROBIOTA associate with the CENTRAL NERVOUS SYSTEM through the axis via microorganism-derived products (e.g., UROCORTINS). Some functional GASTROINTESTINAL DISORDERS (e.g., IRRITABLE BOWEL SYNDROME) have dysregulated brain-gut axis.	Brain and Gut Axis,Brain-Gut-Microbiome Axis,Gut and Brain Axis,Gut-Brain Axis,Gut-Brain-Microbiome Axis,Microbiome-Brain-Gut Axis,Microbiome-Gut-Brain Axis,Microbiota-Brain-Gut Axis,Microbiota-Gut-Brain Axis,Axis, Brain-Gut,Axis, Brain-Gut-Microbiome,Axis, Gut-Brain,Axis, Gut-Brain-Microbiome,Axis, Microbiome-Brain-Gut,Axis, Microbiome-Gut-Brain,Axis, Microbiota-Brain-Gut,Axis, Microbiota-Gut-Brain,Brain Gut Axis,Brain Gut Microbiome Axis,Gut Brain Axis,Gut Brain Microbiome Axis,Microbiome Brain Gut Axis,Microbiome Gut Brain Axis,Microbiota Brain Gut Axis,Microbiota Gut Brain Axis
D001419	Bacteria	One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.	Eubacteria
D012778	Short Bowel Syndrome	A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.	Bowel Syndrome, Short,Bowel Syndromes, Short,Short Bowel Syndromes,Syndrome, Short Bowel,Syndromes, Short Bowel
D064806	Dysbiosis	Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.	Disbacteriosis,Disbiosis,Dys-symbiosis,Dysbacteriosis,Disbacterioses,Disbioses,Dys symbiosis,Dys-symbioses,Dysbacterioses,Dysbioses