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We have purified acidic and basic fibroblast growth factors from human brain (h-aFGF, h-bFGF) and studied the effect of heparin on the growth stimulation by these factors of hamster fibroblast CC139 cells and bovine epithelial lens (BEL) cells. In both the presence and the absence of foetal calf serum (FCS) heparin cooperates with h-aFGF in a dose dependent manner to stimulate both types of cells. The cooperation with h-bFGF is much less. An unpurified human brain fraction containing both factors behaves differently: in the absence of FCS, heparin enhances the activity of the crude fraction on BEL cells, while in the presence of FCS, it decreases this activity. These results indicate that heparin cooperates strongly with h-aFGF to stimulate non-vascular cell proliferation while in a partially purified extract and in the presence of serum it can induce the opposite effect.
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
September 1986,
Journal of cellular physiology,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
October 1990,
Biochemical and biophysical research communications,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
January 1992,
Journal of cellular physiology,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
June 1996,
British journal of haematology,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
January 1991,
Growth factors (Chur, Switzerland),
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
July 1997,
Research communications in molecular pathology and pharmacology,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
December 1995,
Cellular and molecular biology (Noisy-le-Grand, France),
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
January 1991,
Annals of the New York Academy of Sciences,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
June 1987,
Cell differentiation,
S Uhlrich, and
O Lagente, and
M Lenfant, and
Y Courtois
March 1991,
Development (Cambridge, England),
