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Cascade Radical Trifluoromethylthiolation/Cyclization of Dienes To Access SCF3-Containing Medium-Sized Heterocycles. 2023
Zhen Zhang, and
Xiangshan Fang, and
Ayimnisa Aili, and
Shilong Wang, and
Junhong Tang, and
Wanjun Lin, and
Lei Xie, and
Jinchun Chen, and
Kai Sun
College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, P. R. China.
A novel radical cascade trifluoromethylthiolation/cyclization of dienes (N-alkyl-2-(1-phenylvinyl)aniline derivatives) with AgSCF3 has been developed. This approach provides simple and efficient access to a wide range of SCF3-containing medium-sized rings (7/8/9-membered heterocycles). Preliminary mechanistic studies suggest that the reaction is realized through a silver-assisted radical cascade cyclization process. The large-scale experiment and modification of the product reveal the promising utility of this protocol.
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