-transparent.png){kind=logo}
In the acute phase of myocardial infarction it is recognized that serum disopyramide concentrations may be lower than expected. This has generally been attributed to reduced oral bioavailability. This report describes data obtained routinely from 6 patients with acute myocardial infarction and cardiac dysrhythmias treated initially with intravenous disopyramide. Serum disopyramide concentrations were consistently lower than expected, on average by 2.6 micrograms/ml. This was interpreted as being due to relatively high drug clearance, calculated as 6.7 +/- 1.5 l/h, compared to expected values of 3-4 l/h. Dosage schedules determined on the basis of the acute phase pharmacokinetics subsequently produced higher than predicted concentrations at later times on average by 2.8 micrograms/ml. Clearance at this time was calculated to be 3.1 +/- 0.6 l/h. Thus even with intravenous disopyramide therapy there are problems with changing pharmacokinetic parameters after myocardial infarction.
H L Elliott, and
A H Thomson, and
S M Bryson
January 1985,
European journal of clinical pharmacology,
H L Elliott, and
A H Thomson, and
S M Bryson
June 1982,
International journal of clinical pharmacology, therapy, and toxicology,
H L Elliott, and
A H Thomson, and
S M Bryson
March 1982,
British journal of clinical pharmacology,
H L Elliott, and
A H Thomson, and
S M Bryson
July 1979,
Clinical pharmacology and therapeutics,
H L Elliott, and
A H Thomson, and
S M Bryson
December 1983,
The Journal of the Association of Physicians of India,
H L Elliott, and
A H Thomson, and
S M Bryson
December 1977,
Lancet (London, England),
H L Elliott, and
A H Thomson, and
S M Bryson
January 1977,
Lancet (London, England),
H L Elliott, and
A H Thomson, and
S M Bryson
February 1978,
Lancet (London, England),
H L Elliott, and
A H Thomson, and
S M Bryson
March 1978,
Lancet (London, England),
H L Elliott, and
A H Thomson, and
S M Bryson
November 1982,
Arquivos brasileiros de cardiologia,
