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In order to determine the specificity of abnormalities of alcohol metabolism in patients with alcoholic liver disease, blood acetaldehyde concentrations after oral ethanol challenge and the activities of alcohol metabolising enzymes in liver biopsy samples have been determined in patients with alcoholic liver disease and a wide variety of non-alcoholic liver disorders. Significant decreases in hepatic cytosolic aldehyde dehydrogenase activity were associated with significant increases in acetaldehyde concentrations after ethanol in both patient groups compared with control subjects. There was a significant correlation between hepatic cytosolic aldehyde dehydrogenase and mean blood acetaldehyde concentration 30-180 min after ethanol ingestion (y = 17.4-0.45x; r = -0.56; p less than 0.01) confirming the importance of this enzyme in controlling blood acetaldehyde concentrations. These findings suggest that disturbances in alcohol metabolism in patients with alcoholic liver disease are the consequence of liver damage rather than a specific abnormality predisposing to alcohol induced liver injury.
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
August 2016,
Alcohol (Fayetteville, N.Y.),
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
March 1974,
Sovetskaia meditsina,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
June 1993,
Orvosi hetilap,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
May 2022,
Thrombosis research,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
January 2012,
Experimental diabetes research,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
January 2018,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
January 2010,
Oxidative medicine and cellular longevity,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
January 1990,
Alcohol and alcoholism (Oxford, Oxfordshire),
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
September 2005,
Diabetic medicine : a journal of the British Diabetic Association,
K Matthewson, and
H Al Mardini, and
K Bartlett, and
C O Record
January 1985,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
