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The potential for caffeine, administered twice daily by gavage in a total dose of 40 or 80 mg/kg/day, to adversely affect the reproductive performance of male rats was investigated. Treatment was continued through 3 wk of serial mating; mating and dosing were terminated concurrently, after which the sires were autopsied and their testes weighed. Controls were treated similarly with distilled water. Significant dose-related differences were detected for sire body weight, but not for testes weight. The majority of the significant effects on the offspring were for those born to the low-dose sires. Statistically significant differences were sporadically detected for the number of pups born and their body weights and survival; however, these differences were not consistently detected in either a dose- or temporal-related fashion. Thus, caffeine appears to have little potential to produce adverse reproductive effects when administered by gavage to male rats at the levels tested in this study.
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
April 1965,
Helvetica odontologica acta,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
January 1984,
Oncology,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
August 1985,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
October 1972,
Archives of ophthalmology (Chicago, Ill. : 1960),
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
May 1968,
Journal of the National Cancer Institute,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
October 1952,
The Journal of nutrition,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
November 1997,
Obesity research,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
January 2004,
Journal of applied toxicology : JAT,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
September 1980,
Toxicology and applied pharmacology,
K E Whitby, and
T F Collins, and
J J Welsh, and
T N Black, and
M O'Donnell, and
G C Gray, and
S Green, and
W L West
August 1990,
Metabolism: clinical and experimental,
