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The influence of cigarette smoking on plasma theophylline elimination half-life was examined in a group of elderly in-patients, to determine whether the modifying effect of cigarette smoking is also present in this age-group. The plasma theophylline half-life was determined in five non-smokers and seven smokers aged 66-88 years after administration of 320 mg of theophylline syrup. A wide range of plasma theophylline half-lives was observed in each group. However, there was a significant difference (P less than 0.05) between the mean plasma theophylline half-life in smokers (5.41 h, SEM 0.69 h) and non-smokers (10.40 h, SEM 1.90 h). It was concluded that, although plasma theophylline half-life tends to be longer in this age-group, the modifying influence of cigarette smoking on plasma theophylline half-life can be demonstrated in the elderly, as well as in young adults.
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
March 1987,
Journal of clinical pharmacology,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
September 1991,
The Journal of pharmacy and pharmacology,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
September 1990,
Biological psychiatry,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
July 1977,
The American review of respiratory disease,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
June 1987,
British journal of clinical pharmacology,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
August 1971,
British journal of preventive & social medicine,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
July 1987,
Klinische Wochenschrift,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
January 1981,
European journal of clinical pharmacology,
P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
October 1981,
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P W Trembath, and
D D Thorsborne-Palmer, and
B Jarrott, and
J J Hammond, and
D M Prinsley
March 1987,
Methods and findings in experimental and clinical pharmacology,
