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Enteric glial hub cells coordinate intestinal motility. 2023
Marissa A Scavuzzo, and
Katherine C Letai, and
Yuka Maeno-Hikichi, and
William J Wulftange, and
Isha K Shah, and
Jeyashri S Rameshbabu, and
Alka Tomar, and
H Elizabeth Shick, and
Aakash K Shah, and
Ying Xiong, and
Erin F Cohn, and
Kevin C Allan, and
Paul J Tesar
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Enteric glia are the predominant cell type in the enteric nervous system yet their identities and roles in gastrointestinal function are not well classified. Using our optimized single nucleus RNA-sequencing method, we identified distinct molecular classes of enteric glia and defined their morphological and spatial diversity. Our findings revealed a functionally specialized biosensor subtype of enteric glia that we call "hub cells." Deletion of the mechanosensory ion channel PIEZO2 from adult enteric glial hub cells, but not other subtypes of enteric glia, led to defects in intestinal motility and gastric emptying in mice. These results provide insight into the multifaceted functions of different enteric glial cell subtypes in gut health and emphasize that therapies targeting enteric glia could advance the treatment of gastrointestinal diseases.
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