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The dynamics of experimental Shigella infection of chick embryo fibroblasts was studied with the use of electron microscopy. The antibiotic-resistant forms of Sh. sonnei 1,188 was found to be incapable of invasion into the fibroblast cytoplasm and intracellular proliferation. The destruction of fibroblasts observed during the infection was seemingly caused by the action of bacterial endotoxins.
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