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Bacteria of E. coli causing enteritis can be extracted by EDTA-sodium. These extracts having lower dry weights result in better protective effects in contrast to sodium-deoxycholate extracts. The EDTA-sodium extracts can be concentrated, purified and sterile filtrated. Thus the production of polyvalent vaccines is possible. A direct relation exists between the effectiveness of the extracts and the virulence of the strains used for extraction. The more virulent the original strain the better is the protective effect of the vaccine produced by extraction of the original strain. The single components of the polyvalent vaccine show a certain improvement of their protective effects. For estimating the immunizing dose, it is necessary to consider the limiting dose. When exceeding this dose the protective effect or the vaccine does not further increase but remains constant of even decreases. The immunizing dose wanted must be greater than the ED50 but smaller than the limiting dose. Extremely high oral doses of vaccine result in symptoms of incompatibility in mice.
L Austenat, and
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March 1972,
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T Rockstroh
January 1972,
Annali Sclavo; rivista di microbiologia e di immunologia,
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Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
L Austenat, and
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H Mochmann, and
H W Ocklitz, and
W D Grahlow, and
T Rockstroh
January 1969,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
L Austenat, and
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T Rockstroh
January 1977,
Acta microbiologica Academiae Scientiarum Hungaricae,
L Austenat, and
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H W Ocklitz, and
W D Grahlow, and
T Rockstroh
January 1972,
Annali Sclavo; rivista di microbiologia e di immunologia,
L Austenat, and
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H Mochmann, and
H W Ocklitz, and
W D Grahlow, and
T Rockstroh
April 1970,
Veterinary medicine, small animal clinician : VM, SAC,
L Austenat, and
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H W Ocklitz, and
W D Grahlow, and
T Rockstroh
June 1980,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
L Austenat, and
L Hering, and
H Mochmann, and
H W Ocklitz, and
W D Grahlow, and
T Rockstroh
January 1974,
Acta microbiologica Academiae Scientiarum Hungaricae,
