Biomaterial Database

[Effect of vitamin K administration to the mother for prevention of vitamin K deficiency in the neonate]. 1986

T Tamura, and K Takasaki, and T Yanaihara, and M Maruyama, and T Nakayama

The effect of vitamin K(V.K) administration to the mother on the value of the Hepaplastin test (HPT) was studied in 1,000 neonates. The mean value for HPT on 4th day in the breast feeding group (BF) was 42.2%, which was significantly lower than that in the breast formula feeding group (BFF). 1.6% of BF, and 0.5% of BFF showed an HPT value below 20%. Administration of V.K2 to the mother resulted in a significant increase in the HPT value (BF; 58.9%, BFF; 59.1%). None of the cases showed a HPT value below 20% after the V.K administration. 203 neonates who showed a HPT value below 40% were treated with daily doses of 4 mg V.K2. The HPT value improved to over 40% in all cases within 3 days. V.K1 and K2 concentrations in maternal serum and milk were measured by the method using high performance liquid chromatography. Mean concentrations of V.K1 and K2 on the 4th postpartum day in serum were 0.7 and 0.4 ng/ml and those in the milk were 1.4 and 0.9 ng/ml, respectively. V.K1 administration to the mother after delivery significantly increased V.K1 in serum. V.K2 administration also increased serum V.K2 levels. When V.K1 was given to the mother, both V.K1 and K2 levels in the milk increased. Administration of V.K2 resulted only in an increase in V.K2 in the milk. These results indicated that the administration of V.K to the mother improves the HPT value of the neonate and may be useful in preventing V.K deficiency in the neonate.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008403	Mass Screening	Organized periodic procedures performed on large groups of people for the purpose of detecting disease.	Screening,Mass Screenings,Screening, Mass,Screenings,Screenings, Mass
D008895	Milk, Human	Milk that is produced by HUMAN MAMMARY GLANDS.	Breast Milk,Human Milk,Milk, Breast
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014812	Vitamin K	A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
D014813	Vitamin K Deficiency	A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)	Deficiency, Vitamin K,Deficiencies, Vitamin K,Vitamin K Deficiencies
D049590	Postpartum Period	In females, the period that is shortly after giving birth (PARTURITION).	Puerperium,Postpartum,Postpartum Women,Period, Postpartum,Women, Postpartum