Biomaterial Database

The natural history of microsurgical lymphovenous anastomoses: an experimental study. 1986

P Gloviczki, and L H Hollier, and F E Nora, and M P Kaye

Lymphovenous anastomoses have been suggested for the treatment of lymphedema, but the literature lacks evidence of late patency. To determine a method to verify patency, 57 lymphovenous anastomoses were performed in 34 dogs. In vivo cinelymphangiography gave convincing evidence of patency up to 8 months. Eight of 10 anastomoses were patent at 24 hours, 8 of 19 at 2 to 6 weeks, 4 of 6 at 3 months, and 2 of 6 at 8 months. Antiplatelet treatment did not decrease the thrombotic occlusion rate on the venous side, which was the main cause of failure. Scanning electron microscopy showed complete endothelial coverage of suture lines at 4 weeks. Because this study demonstrated that patency of lymphovenous anastomoses can be achieved, the procedure may be considered for the treatment of secondary lymphedema. The occlusion rate is high; therefore, chances of success are better with several anastomoses performed in the early stages of lymphedema, before significant tissue fibrosis and complete loss of lymphatic valvular function develop.

UI	MeSH Term	Description	Entries
D008208	Lymphatic System	A system of organs and tissues that process and transport immune cells and LYMPH.	Lymphatic Systems
D008209	Lymphedema	Edema due to obstruction of lymph vessels or disorders of the lymph nodes.	Milroy's Disease,Congenital Familial Lymphedema,Congenital Hereditary Lymphedema,Early Onset Lymphedema,Hereditary Lymphedema,Hereditary Lymphedema 1,Hereditary Lymphedema Type I,Lymphedema, Early-Onset,Lymphedema, Hereditary, Ia,Milroy Disease,Nonne-Milroy Disease,Nonne-Milroy Lymphedema,Nonne-Milroy-Meige Disease,Primary Congenital Lymphedema,Congenital Hereditary Lymphedemas,Congenital Lymphedema, Primary,Congenital Lymphedemas, Primary,Early Onset Lymphedemas,Early-Onset Lymphedema,Early-Onset Lymphedemas,Hereditary Lymphedema 1s,Hereditary Lymphedema, Congenital,Hereditary Lymphedemas,Hereditary Lymphedemas, Congenital,Lymphedema, Congenital Hereditary,Lymphedema, Early Onset,Lymphedema, Hereditary,Lymphedema, Nonne-Milroy,Lymphedema, Primary Congenital,Lymphedemas,Lymphedemas, Congenital Hereditary,Lymphedemas, Early Onset,Lymphedemas, Early-Onset,Lymphedemas, Hereditary,Lymphedemas, Primary Congenital,Milroys Disease,Nonne Milroy Disease,Nonne Milroy Lymphedema,Nonne Milroy Meige Disease,Primary Congenital Lymphedemas
D008220	Lymphography	Radiographic study of the lymphatic system following injection of dye or contrast medium.	Lymphangiography,Lymphangiographies,Lymphographies
D008297	Male		Males
D008855	Microscopy, Electron, Scanning	Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.	Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D008866	Microsurgery	The performance of surgical procedures with the aid of a microscope.
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D006083	Graft Occlusion, Vascular	Obstruction of flow in biological or prosthetic vascular grafts.	Graft Restenosis, Vascular,Vascular Graft Occlusion,Vascular Graft Restenosis,Graft Restenoses, Vascular,Occlusion, Vascular Graft,Restenosis, Vascular Graft
D000792	Angiography	Radiography of blood vessels after injection of a contrast medium.	Arteriography,Angiogram,Angiograms,Angiographies,Arteriographies