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Atroposelective Synthesis of N-N Axially Chiral Bipyrroles via Rhodium-Catalyzed C-H Insertion Reaction. 2023

Changkai Wang, and Jiangtao Sun
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.

An atroposelective synthesis of bipyrroles with an axially chiral N-N bond has been established via a rhodium-catalyzed C-H bond insertion reaction to provide the desired atropisomers in good yields (up to 97% yield) with good to excellent enantioselectivities (up to 99% ee).

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