Biomaterial Database

Mexiletine: biphasic action on convulsive seizures in rodents. 1986

G J Alexander, and L M Kopeloff, and R B Alexander, and N Chatterjie

Mexiletine, an antiarrhythmic drug, exerted a protective effect in mice against convulsive seizures induced by electroshock or the chemical convulsant, pentylenetetrazol, and against seizures induced in inbred audiosusceptible mice by a sound signal. Administered in large doses, mexiletine produced a hyperkinetic myoclonic syndrome of 30-60 min duration. The hyperkinesia could be controlled by dimethylaminoethanol, phenobarbital and by an experimental anticonvulsive agent, eboracin.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008801	Mexiletine	Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.	KO-1173,KO1173,KOE-1173,Mexiletene,Mexiletine Hydrochloride,Mexitil,Mexitil PL,Mexityl,Novo-Mexiletine,KO 1173,KOE 1173,KOE1173,Novo Mexiletine
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009207	Myoclonus	Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).	Myoclonus, Action,Myoclonus, Nocturnal,Myoclonus, Palatal,Polymyoclonus,Myoclonic Jerk,Myoclonic Jerking,Myoclonus Simplex,Myoclonus, Eyelid,Myoclonus, Intention,Myoclonus, Lower Extremity,Myoclonus, Oculopalatal,Myoclonus, Segmental,Myoclonus, Sleep,Myoclonus, Upper Extremity,Action Myoclonus,Extremity Myoclonus, Lower,Extremity Myoclonus, Upper,Eyelid Myoclonus,Intention Myoclonus,Jerk, Myoclonic,Jerking, Myoclonic,Jerks, Myoclonic,Lower Extremity Myoclonus,Myoclonic Jerks,Nocturnal Myoclonus,Oculopalatal Myoclonus,Palatal Myoclonus,Segmental Myoclonus,Simplex, Myoclonus,Sleep Myoclonus,Upper Extremity Myoclonus
D010433	Pentylenetetrazole	A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.	Leptazole,Pentamethylenetetrazole,Pentetrazole,Cardiazol,Corasol,Corazol,Corazole,Korazol,Korazole,Metrazol,Metrazole,Pentazol,Pentylenetetrazol
D011437	Propylamines	Derivatives of propylamine (the structural formula NH2CH2CH2CH3).
D003642	Deanol	An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.	Dimethylaminoethanol,Astyl,Deanol Bisorcate,Demanol,Demanyl,Dimethylethanolamine,N,N-Dimethyl-2-hydroxyethylamine,N,N-Dimethylethanolamine,Tonibral,Bisorcate, Deanol,N,N Dimethyl 2 hydroxyethylamine
D004597	Electroshock	Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.	Electroconvulsive Shock,Electroconvulsive Shocks,Electroshocks,Shock, Electroconvulsive,Shocks, Electroconvulsive
D006948	Hyperkinesis	Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.	Hyperactivity, Motor,Hyperkinesia,Hyperkinesia, Generalized,Hyperkinetic Movements,Generalized Hyperkinesia,Generalized Hyperkinesias,Hyperkinesias, Generalized,Hyperkinetic Movement,Motor Hyperactivity,Movement, Hyperkinetic,Movements, Hyperkinetic
D000161	Acoustic Stimulation	Use of sound to elicit a response in the nervous system.	Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory