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Synthetic arginine vasopressin (AVP) was infused into 11 hydrated normal subjects at five different infusion rates ranging from 10 to 350 microU X kg-1 X min-1. Each infusion rate was continued for 1 h, and urinary determinations were made on the 30- to 60-min specimens during which time there was no further rise in plasma AVP. Urinary AVP concentrations (microU/ml) and excretion rates (microU/min) increased linearly with increasing infusion rates, and the concentration of AVP in urine increased 120 times more rapid than plasma. Urinary and metabolic clearances of AVP also increased linearly with the maximum urinary clearance being 60.6% of the creatinine clearance. The total metabolic clearance of AVP (including urinary clearance) was 17.8 times that of the urinary clearance of AVP alone. These data clarify the relationships between plasma and urinary AVP in normal hydrated subjects during AVP infusion under steady-state conditions and emphasize the potential advantage of measuring urinary AVP as a monitor of endogenous AVP secretion.
A M Moses, and
E Steciak
January 1990,
The Journal of clinical endocrinology and metabolism,
A M Moses, and
E Steciak
January 1987,
Annals of clinical and laboratory science,
A M Moses, and
E Steciak
January 1992,
Proceedings of the Western Pharmacology Society,
A M Moses, and
E Steciak
December 1979,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
A M Moses, and
E Steciak
April 1989,
Endocrinologia japonica,
A M Moses, and
E Steciak
December 1953,
Bollettino della Societa italiana di biologia sperimentale,
A M Moses, and
E Steciak
June 1983,
Endocrinology,
A M Moses, and
E Steciak
January 1989,
Advances in experimental medicine and biology,
A M Moses, and
E Steciak
May 1988,
Clinical pharmacology and therapeutics,
A M Moses, and
E Steciak
April 1990,
Acta paediatrica Japonica : Overseas edition,
