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We studied verapamil pharmacodynamics and disposition in seven young, ten elderly, and seven very elderly hypertensive males. Maximal decrease in mean (+/- SD) blood pressure tended to be greater in the elderly (-13.5 +/- 5.9 mm Hg) and the very elderly patients (-15.9 +/- 9.6 mm Hg) compared with that in young patients (-7.3 +/- 4.2 mm Hg). Disparate effects on heart rate responses were noted with reflex tachycardia in young patients compared with decreases in heart rate among the elderly and very elderly. Sensitivity to verapamil-induced prolongation in electrocardiographic P-R interval was less in the very elderly, and maximal prolongation in P-R interval induced by verapamil was less in the elderly and very elderly. Verapamil disposition was also age related. Total verapamil clearance was decreased in elderly (10.5 +/- 3.5 mL/min X kg; p less than 0.05) and very elderly (8.0 +/- 4.1 mL/min X kg; p less than 0.01) when compared with that in young patients (15.5 +/- 4.5 mL/min X kg). Elimination half-life was prolonged in the elderly (7.4 +/- 3.3 h; p less than 0.01) and very elderly (8.0 +/- 1.2 h; p less than 0.01) compared with that in young patients (3.8 +/- 1.1 h). Our data indicate age- and hypertension-related physiologic changes result in predictable pharmacokinetic changes. However, the complex alterations in verapamil pharmacodynamic responses indicate an interaction between direct drug effects and age- and disease-related changes in hemodynamic and autonomic nervous system function.
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1984,
Journal of cardiovascular pharmacology,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1988,
Journal of cardiovascular pharmacology,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1982,
The Journal of pharmacology and experimental therapeutics,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
May 1990,
Clinics in geriatric medicine,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
December 1985,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
February 1983,
Archives internationales de pharmacodynamie et de therapie,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1990,
Pharmacotherapy,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1988,
Harefuah,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1983,
Anesthesia and analgesia,
D R Abernethy, and
J B Schwartz, and
E L Todd, and
R Luchi, and
E Snow
January 1997,
The Journal of pharmacy and pharmacology,
