-transparent.png){kind=logo}
Binding of human colostral secretory IgA (SIgA) to Salmonella typhimurium 395 MR10 decreased the liability to hydrophobic interaction of the bacteria, as analysed by hydrophobic interaction chromatography on Octyl-Sepharose and partition in an aqueous polymer two-phase system consisting of dextran, poly(ethyleneglycol) (PEG) and poly-(ethyleneglycol)-palmitate (P--PEG). SIgA also reduced the negative charge of the bacteria. Treatment of the bacteria with centrifuged but not further fractionated colostrum added positive charge to the bacteria which was removed by treatment with pepsin. Colostral SIgA reduced the in vitro phagocytosis of S. typhimurium MR10 by polymorphonuclear leucocytes. The adhesion of the bacteria to cellulose membrane filters in the absence of phagocytes was also reduced after the interaction with SIgA. It is proposed that the binding of SIgA to bacterial surfaces has hydrophilic and anti-adhesive effects, which may serve to exclude antigen from mucosal surfaces.
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
October 1977,
Acta pathologica et microbiologica Scandinavica. Section B, Microbiology,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
August 1973,
Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
August 1977,
Infection and immunity,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
January 1985,
International archives of allergy and applied immunology,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
January 1972,
Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
January 1981,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
January 1984,
Immunological communications,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
April 1981,
Immunology letters,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
May 2003,
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
K E Magnusson, and
O Stendahl, and
I Stjernström, and
L Edebo
December 1980,
Molecular immunology,
