-transparent.png){kind=logo}
TMEM123 a key player in immune surveillance of colorectal cancer. 2023
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
Istituto Nazionale Genetica Molecolare (INGM), Padiglione Romeo ed Enrica Invernizzi, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells determines the balance between tumor elimination or outgrowth. We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 and CD8 T lymphocytes and it contributes to their effector phenotype. The presence of infiltrating TMEM123+ CD8+ T cells is associated with better overall and metastasis-free survival. TMEM123 localizes in the protrusions of infiltrating T cells, it contributes to lymphocyte migration and cytoskeleton organization. TMEM123 silencing modulates the underlying signaling pathways dependent on the cytoskeletal regulator WASP and the Arp2/3 actin nucleation complex, which are required for synaptic force exertion. Using tumoroid-lymphocyte co-culture assays, we found that lymphocytes form clusters through TMEM123, anchoring to cancer cells and contributing to their killing. We propose an active role for TMEM123 in the anti-cancer activity of T cells within tumour microenvironment.
Related Publications
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2017,
Trends in cancer,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2025,
Seminars in cancer biology,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2025,
Current molecular medicine,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
August 2019,
Oncology letters,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2016,
Gastroenterology research and practice,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
December 2022,
Critical reviews in oncology/hematology,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
March 2025,
Science signaling,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2014,
Indian journal of cancer,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
November 2011,
Cancer research,
Elisa Pesce, and
Chiara Cordiglieri, and
Mauro Bombaci, and
Serenella Eppenberger-Castori, and
Stefania Oliveto, and
Cristina Manara, and
Mariacristina Crosti, and
Caner Ercan, and
Mairene Coto, and
Andrea Gobbini, and
Susanna Campagnoli, and
Tiziano Donnarumma, and
Manuele Martinelli, and
Valeria Bevilacqua, and
Elisa De Camilli, and
Paola Gruarin, and
Maria L Sarnicola, and
Elisa Cassinotti, and
Ludovica Baldari, and
Giuseppe Viale, and
Stefano Biffo, and
Sergio Abrignani, and
Luigi M Terracciano, and
Renata Grifantini
January 2012,
Expert review of anticancer therapy,
