-transparent.png){kind=logo}
The synthesis of 1,3,3-trimethyl-N-(2-pyridyl)-2-oxabicyclo-[2.2.2]octan-6-amine (cis, trans mixture) starting from 1,3,3-trimethyl-N-nitro-2-oxabicyclo[2.2.2]octan-6-imine, as well as of a series of amides (V) derived from the above amine, is described. Some compounds (V) showed strong hypotensive activity in rats. Effects on heart rate and antiarrhythmic activity in rats, as well as local anesthetic activity in mice, are also reported.
Related Publications
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
March 1982,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
May 1989,
Farmaco (Societa chimica italiana : 1989),
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
January 1983,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
March 1985,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
April 1982,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
March 1981,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
August 1986,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
April 1994,
Farmaco (Societa chimica italiana : 1989),
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
May 1983,
Il Farmaco; edizione scientifica,
E Mariani, and
O Bruno, and
P Schenone, and
D De Santis, and
G Di Mauro, and
E Marmo
January 1984,
Il Farmaco; edizione scientifica,
