Human exposure to volatile halogenated hydrocarbons from the general environment. 1986

H Hajimiragha, and U Ewers, and R Jansen-Rosseck, and A Brockhaus

The objective of this study was to assess individual human exposure to volatile halogenated hydrocarbons (VHH) under normal environmental conditions by means of biological monitoring, i.e. by the measurement of these compounds or their metabolites in body fluids, such as blood, serum, and urine. Blood samples of 39 normal subjects without known occupational exposure to these agents were examined for the occurrence of VHH. The following compounds were present in quantifiable concentrations in 60 to 95% of the blood samples examined: chloroform (median 0.2 microgram/l; range less than 0.1-1.7 microgram/l), 1,1,1-trichloroethane (median 0.2 microgram/l; range less than 0.1-3.4 micrograms/l), tetrachloroethylene (median 0.4 microgram/l; range less than 0.1-3.7 micrograms/l). Trichloroethylene could be detected in 31% of all blood samples (median less than 0.1 microgram/l; range less than 0.1-1.3 microgram/l). In addition, the levels of trichloroacetic acid (TCA) were determined in serum and 24-h urine samples of 43 and 94, respectively, normal subjects. TCA was present in measurable concentrations in all serum and urine samples examined. The median of the TCA levels in serum was 21.4 micrograms/l (range 4.8-221.2 micrograms/l) and in urine 6.0 micrograms/24 h (range 0.6-261.4 micrograms/24 h). The results are discussed in relation to data from the literature on human exposure to VHH from the general environment, i.e. via air, food, and water. The upper normal limits calculated from the results of this investigation can be used to detect even minor excessive exposures to VHH.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D002849 Chromatography, Gas Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix. Chromatography, Gas-Liquid,Gas Chromatography,Chromatographies, Gas,Chromatographies, Gas-Liquid,Chromatography, Gas Liquid,Gas Chromatographies,Gas-Liquid Chromatographies,Gas-Liquid Chromatography
D004785 Environmental Pollutants Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS. Environmental Pollutant,Pollutant,Pollutants,Pollutants, Environmental,Pollutant, Environmental
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006846 Hydrocarbons, Halogenated Hydrocarbon compounds with one or more HYDROGEN atoms substituted with HALOGENS. Halogenated Hydrocarbons
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014238 Trichloroacetic Acid A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts. Acide trichloracetique,Rubidium Trichloroacetate,Sodium Trichloroacetate,Acid, Trichloroacetic,Trichloroacetate, Rubidium,Trichloroacetate, Sodium,trichloracetique, Acide

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