Impact of Corneal Toricity on the Distribution of Corneal Epithelial Thickness. 2023

Jiafan Zhang, and Sai Liu, and Ting Shao, and Hua Li, and Huifeng Wang, and Keli Long

OBJECTIVE To investigate the impact of corneal toricity on the distribution characteristics of corneal epithelial thickness (CET). METHODS A total of 330 eyes in 330 healthy participants were included in this study. They were divided into two groups based on the median of the corneal toricity value: low-toricity group (corneal toricity < 1.50 diopters) and high-toricity group (corneal toricity ≥ 1.50 diopters). The CET within a 9-mm-diameter area of the central cornea was obtained using optical coherence tomography. The difference of CET value between flat and steep meridians (F-S CET) was defined to evaluate the CET distribution. The F-S CET between the two groups was compared, and the correlations between F-S CET and the corneal toricity were analyzed. RESULTS The CET was thinner in the superior-peripheral area than in other areas. A slight intergroup difference was noted in terms of the F-S CET at the paracentral (0.11 ± 0.93 vs 0.32 ± 0.92, P = .038), midperipheral (0.45 ± 0.78 vs 0.77 ± 0.89, P = .001), and peripheral (3.11 ± 2.18 vs 4.10 ± 2.38, P < .001) zone. In each zone, the difference in F-S CET between the two groups was less than 1 μm. As the area expanded, the F-S CET continued to increase (F = 850.303, P < .001). A weak correlation was observed between F-S CET and corneal toricity (r = 0.103 to 0.240); however, this correlation was not significant in the paracentral zone. Covariance analysis demonstrated that F-S CET was slightly correlated with age, refractive state, and intraocular pressure. CONCLUSIONS The corneal toricity did not significantly affect the distribution of the corneal epithelium in normal corneas. [.

UI MeSH Term Description Entries
D007429 Intraocular Pressure The pressure of the fluids in the eye. Ocular Tension,Intraocular Pressures,Ocular Tensions,Pressure, Intraocular,Pressures, Intraocular,Tension, Ocular,Tensions, Ocular
D012029 Refraction, Ocular Refraction of LIGHT effected by the media of the EYE. Ocular Refraction,Ocular Refractions,Refractions, Ocular
D003315 Cornea The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed) Corneas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D019573 Epithelium, Corneal Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings. Anterior Corneal Epithelium,Corneal Epithelium,Corneal Epithelium, Anterior,Epithelium, Anterior Corneal
D041623 Tomography, Optical Coherence An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes. OCT Tomography,Optical Coherence Tomography,Coherence Tomography, Optical,Tomography, OCT

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