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The metabolism of ethanol can result in depletion of reduced glutathione (GSH) via adduct formation and oxidation to GSSG. In this study, the glutathione concentration in liver tissue of chronic alcoholic patients (n = 20) was measured using a specific chromatographic method. The results are compared to values obtained from a group of selected controls (n = 10), and correlated to liver histology and blood biochemistry. All of the alcoholics had markedly lower hepatic GSH concentrations than the control group (medians = 2.17 vs 3.88 mumol/g liver, respectively). No significant differences in liver GSH were found among alcoholic subgroups who had slightly altered or normal histology and/or blood tests vs those with advanced pathology. A decrease in hepatic GSH concentration seems to be a consistent characteristic of chronic alcohol abuse which occurs even in the absence of evident liver damage.
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
January 1988,
Life sciences,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
January 2018,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
October 1988,
Digestive diseases and sciences,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
January 2004,
Alcoholism, clinical and experimental research,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
March 1984,
Clinical science (London, England : 1979),
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
January 1976,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
June 1991,
Orvosi hetilap,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
April 1985,
Gastroenterologie clinique et biologique,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
October 1999,
Pancreas,
S A Jewell, and
D Di Monte, and
A Gentile, and
A Guglielmi, and
E Altomare, and
O Albano
March 1976,
European journal of clinical pharmacology,
