| D009707 |
Nucleosomes |
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4. |
Dinucleosomes,Polynucleosomes,Dinucleosome,Nucleosome,Polynucleosome |
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| D006657 |
Histones |
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. |
Histone,Histone H1,Histone H1(s),Histone H2a,Histone H2b,Histone H3,Histone H3.3,Histone H4,Histone H5,Histone H7 |
|
| D000107 |
Acetylation |
Formation of an acetyl derivative. (Stedman, 25th ed) |
Acetylations |
|
| D044127 |
Epigenesis, Genetic |
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression. |
Epigenetic Processes,Epigenetic Process,Epigenetics Processes,Genetic Epigenesis,Process, Epigenetic,Processes, Epigenetic,Processes, Epigenetics |
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| D050880 |
p300-CBP Transcription Factors |
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION. |
p300-CBP Coactivator,p300-CBP Protein,Coactivator, p300-CBP,Transcription Factors, p300-CBP,p300 CBP Coactivator,p300 CBP Protein,p300 CBP Transcription Factors |
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| D050882 |
CREB-Binding Protein |
A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME. |
Nuclear Protein CBP,Phospho-CREB-Binding Protein,CBP, Nuclear Protein,CREB Binding Protein,Phospho CREB Binding Protein |
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