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We have developed an interactive computer system for analysing cell lineage data. It can be utilized in studies of cell motility, cell division, cell differentiation, and cell aging. It has enabled us to document the heterogeneity of human foreskin fibroblasts in culture and to propose that loss of proliferative potential may mean that cells enter a state of differentiation which makes them unable to respond to mitotic stimulation. Our method, which enables us to apply immunological and cytochemical probes after recording the history of a cell lineage, should allow us to define precisely features which uniquely distinguish cycling from noncycling cells on an individual cell basis.
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
July 1976,
Medical care,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
January 1995,
M.D. computing : computers in medical practice,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
February 1969,
Computers and biomedical research, an international journal,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
January 1978,
Drug information journal,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
April 1976,
Computer programs in biomedicine,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
January 1973,
Medical arts and sciences,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
November 1971,
The British journal of radiology,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
September 1974,
Computers in biology and medicine,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
January 1979,
Computers in biology and medicine,
E Bell, and
D Levinstone, and
S Sher, and
L Marek, and
C Merrill, and
I Young, and
M Eden
February 1987,
Computers and biomedical research, an international journal,
