Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4. 1986

R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard

UI MeSH Term Description Entries
D007082 Ileum The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D010654 Phenylbutyrates Derivatives of 4-phenylbutyric acid, including its salts and esters.
D001980 Bronchi The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI. Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001681 Biological Assay A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc. Bioassay,Assay, Biological,Assays, Biological,Biologic Assay,Biologic Assays,Assay, Biologic,Assays, Biologic,Bioassays,Biological Assays
D013189 SRS-A A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed) Slow Reacting Substance of Anaphylaxis
D014132 Trachea The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Tracheas

Related Publications

R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
August 1986, Canadian journal of physiology and pharmacology,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
December 1986, Canadian journal of physiology and pharmacology,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
May 1988, Arzneimittel-Forschung,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
June 1989, Journal of medicinal chemistry,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
January 1988, Drug metabolism and disposition: the biological fate of chemicals,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
February 1987, Journal of pharmaceutical sciences,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
January 1988, Drug metabolism and disposition: the biological fate of chemicals,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
July 1987, Journal of chromatography,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
August 2001, Bioorganic & medicinal chemistry letters,
R N Young, and P Bélanger, and E Champion, and R N DeHaven, and D Denis, and A W Ford-Hutchinson, and R Fortin, and R Frenette, and J Y Gauthier, and J Gillard
April 1985, The Journal of pharmacology and experimental therapeutics,
Copied contents to your clipboard!