The authors described the use of radionuclide ventriculography in dynamic and static variants to determine left ventricle volumetric values. The results obtained were correlated with those of roentgeno-contrast ventriculography (the correlation coefficient R was 86.8%) and literature data on echocardiography. The end-diastolic, end-systolic and stroke volumes (EDV, ESV and SV), the mean ejection rate (MER) and the total ejection fraction (TEF) were determined in controls and patients with chronic CHD. With growing severity of disease, EDV, ESV were on the increase, whereas SV and MER were on the decrease. The determination of left ventricle volumetric values permitted improved diagnosis and differential diagnosis of cardiovascular diseases.