BIOMAT Database Logo BIOMAT Database Logo

Clinical efficacy of centrifugal-membranous hybrid double filtration plasmapheresis and membranous double filtration plasmapheresis on severe lupus nephritis. 2023

Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
National Clinical Research Center of kidney Diseases, JinLing Hospital, Nanjing University School of medicine, Nanjing, China.

OBJECTIVE The study delves into the clinical efficacy and safety of centrifugal-membranous hybrid double filtration plasmapheresis (C/M hybrid DFPP) on severe lupus nephritis (LN) by comparing it with membranous DFPP (M DFPP). METHODS A retrospective cohort study was conducted in 70 patients who were diagnosed with severe LN and had received DFPP treatment. RESULTS A total of 181 DFPPs were performed, including 133 C/M hybrid DFPPs (51 patients) and 48 M DFPPs (19 patients).The ANA, A-dsDNA titer, quantitative urinary protein, and serum creatinine decreased significantly and hemoglobin increased significantly after the DFPP treatment and at third month after treatment. Two patients in the M DFPP group developed bleeding complications, and four patients in the C/M hybrid DFPP group developed perioral numbness. CONCLUSIONS Although there was no significant difference in clinical efficacy between C/M hybrid DFPP and M DFPP on severe LN, the risk of bleeding complications was significantly lower in the C/M hybrid DFPP group.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008181 Lupus Nephritis Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982). Glomerulonephritis, Lupus,Lupus Glomerulonephritis,Nephritis, Lupus,Glomerulonephritides, Lupus,Lupus Glomerulonephritides,Lupus Nephritides,Nephritides, Lupus
D010956 Plasmapheresis Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use. Double Filtration Plasmapheresis,Therapeutic Immunoadsorption,Therapeutic Plasma Adsorption,Therapeutic Plasmapheresis,Adsorption, Therapeutic Plasma,Adsorptions, Therapeutic Plasma,Double Filtration Plasmaphereses,Filtration Plasmapheresis, Double,Immunoadsorption, Therapeutic,Plasma Adsorption, Therapeutic,Plasmaphereses,Plasmapheresis, Double Filtration,Plasmapheresis, Therapeutic,Therapeutic Immunoadsorptions,Therapeutic Plasma Adsorptions,Therapeutic Plasmaphereses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes

Related Publications

Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Comparison of three modalities of plasmapheresis on coagulation: Centrifugal, single-membrane filtration, and double-filtration plasmapheresis.
June 2021, Journal of clinical apheresis,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Therapeutic effect of double plasmapheresis combined with immunosuppressive agents on severe lupus nephritis.
April 2023, Minerva medica,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Therapeutic effect of double-filtration plasmapheresis combined with methylprednisolone to treat diffuse proliferative lupus nephritis.
August 2016, Journal of clinical apheresis,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Membranous Lupus Nephritis: A Clinical Review.
September 2019, Advances in chronic kidney disease,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Treatment of steroid-resistant membranous lupus nephritis with plasmapheresis and low-dose cyclosporine.
April 2007, Pediatric nephrology (Berlin, Germany),
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Membranous lupus nephritis.
January 2005, Lupus,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Plasmapheresis for lupus nephritis. Lupus Plasmapheresis Study Group.
October 1992, The New England journal of medicine,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
EFFICACY OF DOUBLE FILTRATION PLASMAPHERESIS TREATMENT IN ACUTE PANCREATITIS ASSOCIATED WITH SEVERE HYPERTRIGLYCERIDEMIA.
January 2023, Acta endocrinologica (Bucharest, Romania : 2005),
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Double-filtration plasmapheresis.
December 2007, Transplantation,
Jianhua Dong, and Li Huang, and Chuan Li, and Bian Wu, and Xi Yang, and Yongchun Ge
Double filtration plasmapheresis.
January 1980, Transactions - American Society for Artificial Internal Organs,
Copied contents to your clipboard!