BIOMAT Database Logo BIOMAT Database Logo

Comparison of the Effects of Monounsaturated Fatty Acids and Polyunsaturated Fatty Acids on Liver Lipid Disorders in Obese Mice. 2023

Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Department of Clinical Nutrition and Key Laboratory of Transplant Engineering and Immunology, NHFPC, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide spectrum of metabolic diseases including type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have been reported to combat SFA-induced cellular damage. However, the comparative studies of the two types of unsaturated fatty acids (UFAs) are still limited. We investigated the effects of different MUFAs and PUFAs in the human hepatocyte line L-02 cells in vitro, and in high-fat-diet (HFD)-induced obese C57BL/6 mice in vivo. The results of the in vitro study showed that SFAs induced significant cellular lipotoxic damage, but the combination of MUFAs/PUFAs with SFAs significantly improved the impaired cell viability. Particularly, oleic acid (OA) was superior to eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), and arachidonic acid (AA) in terms of its anti-apoptotic effect and inhibition of endoplasmic reticulum (ER) stress. In vivo, both olive-oil-enriched (HFD + OO) and fish-oil-enriched high-fat diets (HFD + FO) reduced hepatic steatosis and improved insulin sensitivity in obese mice. However, FO induced an abnormal increase in serum aspartate aminotransferase (AST) and an increase in the oxidative stress indicator Malondialdehyde (MDA). Liver-targeted lipidomic analysis showed that liver lipid metabolites under the two types of UFA dietary interventions differed from the HFD group, modulating the abundance of some lipid metabolites such as triglycerides (TGs) and glycerophospholipids. Furthermore, the FO diet significantly increased the abundance of the associated FA 20:5 long-chain lipid metabolites, whereas the OO diet regulated the unsaturation of all fatty acids in general and increased the abundance of FA 18:1 in the overall lipid metabolites, especially TGs, which may primarily contribute to the FO, and OO drove protection in NAFLD.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008820 Mice, Obese Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid. Hyperglycemic Mice,Obese Mice,Mouse, Hyperglycemic,Mouse, Obese,Hyperglycemic Mouse,Mice, Hyperglycemic,Obese Mouse
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D005229 Fatty Acids, Monounsaturated Fatty acids which are unsaturated in only one position. Monounsaturated Fatty Acid,Acid, Monounsaturated Fatty,Acids, Monounsaturated Fatty,Fatty Acid, Monounsaturated,Monounsaturated Fatty Acids
D005231 Fatty Acids, Unsaturated FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds. Fatty Acids, Polyunsaturated,Polyunsaturated Fatty Acid,Unsaturated Fatty Acid,Polyunsaturated Fatty Acids,Acid, Polyunsaturated Fatty,Acid, Unsaturated Fatty,Acids, Polyunsaturated Fatty,Acids, Unsaturated Fatty,Fatty Acid, Polyunsaturated,Fatty Acid, Unsaturated,Unsaturated Fatty Acids
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Effect of polyunsaturated fatty acids in obese mice.
March 1996, Lipids,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Comparative effects of polyunsaturated- to saturated fatty acid ratio versus polyunsaturated- and monounsaturated fatty acids to saturated fatty acid ratio on lipid metabolism in rats.
January 1999, Atherosclerosis,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Long-term effects of dietary monounsaturated and polyunsaturated fatty acids on the lipid composition of erythrocyte membranes in dogs.
May 1992, Comparative biochemistry and physiology. Comparative physiology,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man.
February 1985, Journal of lipid research,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Effects of the ratio of polyunsaturated and monounsaturated fatty acid to saturated fatty acid on rat plasma and liver lipid concentrations.
May 1998, Lipids,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Effects of polyunsaturated fatty acids on psychiatric disorders.
November 2000, The American journal of clinical nutrition,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Lipid-lowering diets enriched with monounsaturated or polyunsaturated fatty acids but low in saturated fatty acids have similar effects on serum lipid concentrations in hyperlipidemic patients.
January 1994, The American journal of clinical nutrition,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Dietary monounsaturated and polyunsaturated fatty acids are comparable in their effects on hepatic apolipoprotein mRNA abundance and liver lipid concentrations when substituted for saturated fatty acids in cynomolgus monkeys.
March 1995, The Journal of nutrition,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Supplementation of monounsaturated and polyunsaturated fatty acids in non-alcoholic fatty liver disease and metabolic syndrome.
May 2011, Lipids,
Wen Liu, and Min Zhu, and Meng Gong, and Wen Zheng, and Xin Zeng, and Qing Zheng, and Xiaoyu Li, and Fudong Fu, and Yingyi Chen, and Jingqiu Cheng, and Zhiyong Rao, and Yanrong Lu, and Younan Chen
Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats.
February 1993, The American journal of clinical nutrition,
Copied contents to your clipboard!