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A 2-year prospective double-blind study of prophylactic antibiotics in 317 patients undergoing elective total abdominal or vaginal hysterectomy was conducted. Patients randomly received placebo, penicillin, or cefazolin 30 minutes prior to surgery and at 6-hour intervals thereafter for 48 hours. Rigid criteria for postoperative morbidity were established. Vaginal hysterectomy patients given either penicillin or cefazolin prophylaxis had fewer postoperative infections (P less than 0.01) compared to those given placebo. A similar trend was noted among women undergoing abdominal hysterectomy; however, this trend was not statistically significant (P greater than 0.05). Despite continuous surveillance, no change in nosocomial flora or antibiotic sensitivity of bacterial isolates was noted. Adverse drug effects and antibiotic-resistant secondary infections were encountered with similar frequency in all treatment groups.
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
July 1975,
Military medicine,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
January 1991,
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J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
May 1987,
Zhonghua fu chan ke za zhi,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
January 1988,
Jugoslavenska ginekologija i perinatologija,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
March 2024,
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J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
June 2007,
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J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
January 1988,
Medicinski pregled,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
June 2017,
Archives of gynecology and obstetrics,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
May 1980,
British journal of hospital medicine,
J H Grossman, and
T P Greco, and
M J Minkin, and
R L Adams, and
W J Hierholzer, and
V T Andriole
September 1983,
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